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A03. Functional design of soft molecular systems
Synthetic design of function is a goal in materials sciences, and desirable control of biomolecular function is a goal in life sciences. Recent advances in synthetic chemistry and genetic engineering achieved supramolecular construction and elucidation of biomolecular function, respectively, whereas new functional design has been very limited out of these molecular systems. Understanding of structural dynamics of soft molecular systems is important for new functional expression.
In A03 project, we will create new functions of soft molecular systems using synthetic chemistry and genetic engineering. In soft supramolecular systems, new functions will be designed based on self-assembled materials. In soft biomolecular systems, functional conversions and modifications will be attained by use of site-directed mutagenesis. We believe “softness” and “flexibility” of these complex molecular systems being a key to successful functional design. For this aim, we will collaborate with the groups of theoretical and computational chemistry (A01 project) and those of advanced spectroscopic techniques (A02 project), leading to original functional design of soft molecular systems.
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TOPICS |
Supramolecules and biomolecules for new functional designs in this project
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Theme
- Functional design of soft molecular systems by use of synthetic chemistry
- Functional design of supramolecular assembles by self-organization
- Functional design of soft biomolecular systems by use of genetic engineering
Keywords
Supramolecule, Material Design, Amino-Acid Mutation, Functional Conversion, Structural Dynamics
Research Area
Synthetic Chemistry, Complex Chemistry, Polymer Chemistry, Biochemistry
Planned Research Members
"Soft" structure-function relationship revealed by functional conversion of photoreceptive proteins
Leader: |
Hideki KANDORI |
Graduate School of Engineering, Nagoya Institute of Technology, Professor |
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Keiichi INOUE |
Graduate School of Engineering, Nagoya Institute of Technology, Associate Professor |
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Kota KATAYAMA |
Graduate School of Engineering, Nagoya Institute of Technology, Assistant Professor |
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Daichi YAMADA |
Graduate School of Engineering, Nagoya Institute of Technology, Adjunct Assistant Professor |
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Tatsuya IWATA |
Graduate School of Medicine, Toho University, Associate Professor |
Organo-transition Metal Clusters: Synthesis and Elucidation of Dynamic Structures
Leader: |
Tetsuro MURAHASHI |
Department of Chemical Science and Engineering, School of Materials Science and Chemical Technology, Tokyo Institute of Technology, Professor |
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Koji YAMAMOTO |
Research Center of Integrative Molecular Systems, Institute for Molecular Science, Assistant Professor |
Development of Photo-Responsive Supramolecular Materials with Precise Molecular Design
Leader: |
Takashi NAKANISHI |
International Center for Materials Nanoarchitectonics, National Institute for Materials Science, Group Leader |
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Michito YOSHIZAWA |
Institute of Innovative Research, Tokyo Institute of Technology, Associate Professor |
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Shinsuke ISHIHARA |
International Center for Materials Nanoarchitectonics, National Institute for Materials Science, Senior Researcher |
Proposed Research Subjects (2016-2017)
Development of Mechanoresponsive Luminescent Materials Utilizing Flexible Cyclophanes
Leader: |
Yoshimitsu SAGARA |
Research Institute for Electronic Science, Laboratory of Smart Molecules, Hokkaido University, Assistant Professor |
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Nobuyuki TAMAOKI |
Research Institute for Electronic Science, Laboratory of Smart Molecules, Hokkaido University, Professor |
Study of structure effect of proline-type non-natural amino acids incorporated in α-amino acid peptides
Leader: |
Yuko OTANI |
Graduate School of Pharmaceutical Sciences, The University of Tokyo, Lecturer |
Design and Synthesis of Fluorescent Probes Utilizing Structural Dynamics of Small Organic Molecules
Leader: |
Kenjiro HANAOKA |
Graduate School of Pharmaceutical Sciences, The University of Tokyo, Associate Professor |
Integration and Optical Properties of Helicenes with Nonplanar π-Conjugated Skeletons
Leader: |
Koji NAKANO |
Department of Organic and Polymer Materials Chemistry, Tokyo University of Agriculture and Technology, Associate Professor |
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Masanobu NAITO |
Research Center for Strategic Materials, National Institute for Materials Science, Principal Researcher |
Design of Protein Crystals as Soft Porous Materials
Leader: |
Satoshi ABE |
School of Life Science and Technology, Tokyo Institute of Technology, Assistant Professor |
Functioning Mechanism and Its Application of RNA Aptamer, Switching Device and Sliding of Protein
Leader: |
Masato KATAHIRA |
Institute of Advanced Energy, Kyoto University, Professor |
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Takashi NAGATA |
Institute of Advanced Energy, Kyoto University, Associate Professor |
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Tsukasa MASHIMA |
Institute of Advanced Energy, Kyoto University, Assistant Professor |
Design and synthesis of molecular wire with high charge mobility based on soft-hard transformation of polymer chain
Leader: |
Jun TERAO |
Graduate School of Art and Sciences, The University of Tokyo, Professor |
Construction of Highly-Active Artificial Metalloenzymes with Soft Protein Matrices by Rational Design
Leader: |
Koji OOHORA |
Graduate School of Engineering, Osaka University, Assistant Professor |
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Takashi HAYASHI |
Graduate School of Engineering, Osaka University, Professor |
Creation of functional protein oligomers utilizing the structural change of the flexible loop region
Leader: |
Shun HIROTA |
Graduate School of Materials Science, Nara Institute of Science and Technology, Professor |
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Satoshi NAGAO |
Graduate School of Materials Science, Nara Institute of Science and Technology, Assistant Professor |
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Masaru YAMANAKA |
Graduate School of Materials Science, Nara Institute of Science and Technology, Assistant Professor |
Development of Polymeric Materials with Densely Accumulated Functional Groups via Controlled Polymerization of Diazoacetates
Leader: |
Eiji IHARA |
Graduate School of Science and Engineering, Ehime University, Professor |
Development of Switchable Soft Molecular Crystals
Leader: |
Osamu SATO |
Institute for Materials Chemistry and Engineering, Kyushu University, Professor |
New Excitonic Functions Developed in Soft Condensed Molecular Systems
Leader: |
Nobuhiro YANAI |
Department of Chemistry and Biochemistry, Kyushu University, Associate Professor |
Creation of Photoresponsive Organic Ferroelectrics with Strong Correlation between Proton Transfer and Photoisomerization Reactions
Leader: |
Masakazu MORIMOTO |
Department of Chemistry, Rikkyo University, Professor |
Proposed Research Subjects (2014-2015)
Regular structure of oligomers of unnatural proline analogs with flexible amide bonds
Leader: |
Yuko OTANI |
Graduate School of Pharmaceutical Sciences, The University of Tokyo, Lecturer |
Development of Fluorescence Probes Utilizing Structural Dynamics of Azo Group
Leader: |
Kenjiro HANAOKA |
Graduate School of Pharmaceutical Sciences, The University of Tokyo, Associate Professor |
Development of Functional Materials Composed of Twisted π-Conjugated Molecules
Leader: |
Koji NAKANO |
Department of Organic and Polymer Materials Chemistry, Tokyo University of Agriculture and Technology, Senior Assistant Professor |
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Masanobu NAITO |
Environment and Energy Materials Division, National Institute for Materials Science, Principal Researcher |
Mechanism of Bifunction of RNA, Trapping of Protein and Switching of Enzymatic Activity
Leader: |
Masato KATAHIRA |
Institute of Advanced Energy, Kyoto University, Professor |
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Takashi NAGATA |
Institute of Advanced Energy, Kyoto University, Associate Professor |
Most Suitable Molecular Design and Synthesis for Enthalpy Control of Conductive Polymer Chain
Leader: |
Jun TERAO |
Graduate School of Engineering, Kyoto University, Associate Professor |
Rational Design and Construction of Enantioselective Artificial Metalloenzymes with Soft Protein Matrices
Leader: |
Koji OOHORA |
Graduate School of Engineering, Osaka University, Assistant Professor |
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Takashi HAYASHI |
Graduate School of Engineering, Osaka University, Professor |
Development of Metallocenium Ionic Liquids Exhibiting Unconventional Chemical and Physical Properties
Leader: |
Tomoyuki MOCHIDA |
Graduate School of Science, Kobe University, Professor |
Application of Poly(Substituted Methylene)s as Soft Molecular System
Leader: |
Eiji IHARA |
Graduate School of Science and Engineering, Ehime University, Professor |
Development of Stimuli Responsive Soft Molecular Crystals
Leader: |
Osamu SATO |
Institute for Materials Chemistry and Engineering , Kyushu University, Professor |
Development of Photon-Upconverting Ionic Liquids
Leader: |
Nobuhiro YANAI |
Department of Chemistry and Biochemistry, Kyushu University, Assistant Professor |
Photochromic Molecular Crystals that Change their Physical Properties by Light-Induced Structural Transformation
Leader: |
Masakazu MORIMOTO |
Department of Chemistry, Rikkyo University, Associate Professor |
Developments of assembly of non-planer conjugated molecules based on dynamic analysis
Leader: |
Waka NAKANISHI |
International Center for Materials Nanoarchitectonics, National Institute for Materials Science, Scientist |
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